Patient Derived Tumor Xenograft Models Promise Potential And Practice

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Table of Contents

• Contents (p.7)
• Preface (p.27)
• 1 - PDX Models: History and Development (p.31)
• REFERENCES (p.38)
• 2 - History of Mouse Cancer Models (p.43)
• REFERENCES (p.50)
• 3 - Challenges and Limitations of Mouse Xenograft Models of Cancer (p.53)
• REFERENCES (p.61)
• 4 - Tumor Heterogeneity (p.65)
• REFERENCES (p.78)
• 5 - Immunodeficient Mice: The Backbone of Patient-Derived Tumor Xenograft Models (p.85)
• REFERENCES (p.99)
• 6 - Humanized Mice and PDX Models (p.103)
• REFERENCES (p.114)
• 1 - Regulations of Patient-Derived Xenografts (p.121)
• REFERENCES (p.134)
• 2 - Acquisition and Storage of Clinical Samples to Establish PDX Models (p.137)
• REFERENCES (p.146)
• 3 - Methodologies for Developing and Maintaining Patient-Derived Xenograft Mouse Models (p.147)
• REFERENCES (p.160)
• 4 - Pathology of Patient-Derived Xenograft Tumors (p.163)
• REFERENCES (p.174)
• 5 - Genetic Profiling of Tumors in PDX Models (p.177)
• REFERENCES (p.186)
• 6 - Running a PDX Core Laboratory or a PDX Support Program (p.189)
• REFERENCES (p.200)
• 7 - Veterinary Care (p.201)
• REFERENCES (p.209)
• 8 - Occupational Health and Safety (p.215)
• REFERENCES (p.227)
• 1 - Pediatric and Adult Brain Tumor PDX Models (p.233)
• REFERENCES (p.241)
• 2 - Patient-Derived Xenograft Models of Prostate Tumors (p.245)
• REFERENCES (p.253)
• 3 - Patient-Derived Xenograft Model of Pancreatic Cancer (p.257)
• REFERENCES (p.267)
• 4 - Modeling Breast Cancer Heterogeneity With Patient-Derived Xenografts (p.271)
• REFERENCES (p.283)
• 5 - Patient-Derived Xenograft Models of Ovarian/Gynecologic Tumors (p.285)
• REFERENCES (p.296)
• 6 - Patient-Derived Xenografts From Lung Cancer and Their Potential Applications (p.301)
• REFERENCES (p.311)
• 7 - PDX Models of Colorectal Tumors (p.319)
• REFERENCES (p.330)
• 8 - Patient-Derived Tumor Xenografts in Hematologic Disorders (p.333)
• REFERENCES (p.358)
• 9 - Patient-Derived Xenografting of Human Melanoma (p.369)
• REFERENCES (p.386)
• 10 - Advances in Organoid Culturing of Patient-Derived Tumors (p.393)
• REFERENCES (p.400)
• 1 - Global Practices in PDX Programs (p.407)
• REFERENCES (p.432)
• 2 - Role of Companies and Corporations in the Development and Utilization of PDX Models (p.437)
• APPENDIX 1. ADDITIONAL INFORMATION ON SOME COMPANIES PROVIDING AND SUPPORTING PDX MODEL DEVELOPMENT (p.452)
• REFERENCES (p.454)
• 1 - Patient-Derived Tumor Xenograft: Present and Future Challenges and Applications (p.457)
• REFERENCES (p.473)
• Index (p.481)
• ... and 419 more chapters

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